电子断层成像技术在两种纳米材料中的应用
李茵茵1#,蒋中鸣2#,李红梅1,贾旭东1,张勤奋1*
(1.中山大学 生命科学学院,广东 广州 510275;2.昆明理工大学 材料科学与工程系,云南 昆明 650093)
摘 要:本文通过使用电子断层成像技术,分别对纳米金样品和纳米囊泡药物两种材料进行多角度成像研究,发现纳米金样品为圆盘状,并没有棒状结构,同时还测量了纳米金盘的厚度。纳米囊泡拟包含药物为膜状结构而非针状或棒状。多角度成像排除了二维电镜图片的假象,显示电子断层成像技术在纳米材料的应用前景。
关键词:电子断层成像技术;纳米金样品;纳米囊泡药物
中图分类号:TG115.21+5.3;TN16;TB383 文献标识码:A doi:10.3969/j.issn.1000-6281.2016.05.007
The application of electron tomography to the investigation of two nano materials
LI Yin-yin1#,JIANG Zhong-ming2#,LI Hong-mei1,JIA Xu-dong1,ZHANG Qin-fen1*
(1.School of Life Sciences, Sun Yat-Sen University,Guangzhou Guangdong 510275;2. Department of Material Science and Engineering, Kunming University of Science and Technology, Kunming Yunnan 650093, China)
Abstract The nano Au particles and nano-drugs were studied by Electron tomography (ET). The results reveal that the nano-Au particles are disk like structure, and no rod structure is found. The thickness of the Au disc is calculated. The nano-drugs inside the liposomes are membrane-like structure, not rod or needle. Some false 2D projections can be effectively excluded by ET. ET is a promising technology for nano materials.
Keywords electron tomography;nano Au particle;nano-drugs
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收稿日期:2016-04-06;修订日期:2016-04-20
基金项目:国家自然科学基金资助项目(No. 31570736,No.);NSFC-RGC资助项目(No. 31361163001).
作者简介:李茵茵(1981-),女(汉族),广东人,助理实验师. E-mail:liyinyin@mail.sysu.edu.cn
#共同第一作者
*通讯作者:张勤奋(1966-),女(汉族),副教授. E-mail:lsszqf@mail.sysu.edu.cn
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