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液态金属微球的微观结构与血管栓塞性能研究

沈晨宇，甘雅玲，蔣文溪，张维强，陈军歌✻，梁兴杰✻，王志军✻
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2024年 第43卷 第3期:  1000-6281（2024）03-324-005     下载地址：

液态金属微球的微观结构与血管栓塞性能研究

沈晨宇，甘雅玲，蔣文溪，张维强，陈军歌✻，梁兴杰✻，王志军✻

(1. 中国人民解放军总医院，北京100853；2. 北京航空航天大学医学科学与工程学院，北京100083；3. 国家纳米科学中心，北京100190；4. 中国科学院大学，北京100049；5. 军委联合参谋部警卫局卫生保健处，北京100017）

摘  要 本文制备了一种液态金属微球，并对该液态金属微球的微观结构和血管内栓塞效果进行了研究。结果表明：在光学显微镜与电子显微镜下观察到液态金属微球呈球形，在对其元素分析中观察到了镓元素和氧元素；在对兔子耳中央动脉的栓塞实验中，发现液态金属微球成功地阻断了兔子耳中央动脉，导致了兔耳的坏死。当液态金属微球的直径与血管的直径相当时，便会通过物理栓塞方式阻塞血管。同时，液态金属微球因其自身的高密度具有X射线显影性。栓塞前与栓塞后的血液检查和主要器官组织病理表明，液态金属微球有着良好的生物相容性。因此，液态金属微球是一种极具潜在临床应用价值的栓塞材料。

关键词  液态金属微球；栓塞；镓；X射线可视；微观结构

中图分类号：R81；R318；Q336  文献标识码：A            doi：10.3969/j.issn.1000-6281.2024.03.008

    

Microstructure and vascular embolic properties of liquid metal microspheres

SHEN Chenyu1, GAN Yaling3，4, JIANG Wenxi5, ZHANG Weiqiang5, CHEN Junge2*,

LIANG Xingjie3，4*, WANG Zhijun1*

（1. Chinese People’s Liberation Army General Hospital, Beijing 100083；2. School of Engineering Medicine, Beihang University, Beijing 100083；3. National Centre for Nanoscience and Technology, Beijing 100190；4. University of Chinese Academy of Sciences, Beijing 100049；5.Health Service Department of the Guard Bureau of the General Office of the Central Committee of the Communist Party of China, Beijing 100017, China）

Abstract  In this paper, a liquid metal microsphere was prepared. The microstructure and intravascular embolization effect of the liquid metal microsphere were investigated. The results showed that it had a spherical morphology observed by a microscope. Gallium and oxygen elements were detected by elemental analyses. Liquid metal microspheres blocked the central artery of rabbit's ear, leading to necrosis of the rabbit's ear during the embolization experiments on the rabbit's central ear artery. Blood vessels were blocked by physical embolization when the diameter of the liquid metal microspheres was comparable to that of blood vessels. Liquid metal microspheres were X-ray visible due to their high density. Pre- and post-embolization blood tests and histopathology of major organs showed that liquid metal microspheres had good biocompatibility. Therefore, liquid metal microsphere is an embolization material for great potential clinical applications.

Keywords  liquid metal microspheres；embolization；gallium；X-ray visualization；microstructure

 

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